Also known as solidcystic or clear cell hidradenoma is a benign adnexal tumor that arises from the distal excretory duct of eccrine sweat glands. Nodules with cystic foci high in dermis microscopic histologic description. Malignant transformation of nodular hidradenoma in the lower leg. Hidradenocarcinoma genetic and rare diseases information. Benign nodular hidradenoma is known by many names such as solid cystic hidradenoma, clear cell myoepithelioma, eccrine sweat gland adenoma, large cell hidradenoma and eccrineacrospiroma. Scalp is a known and yet uncommon site of occurrence. The tumour range from locally recurring, low grade well differentiated tumour to highly aggressive high grade tumour with potential for local and distant metastasis to. Nodular hidradenoma is an uncommon cutaneous adnexal tumor arising from sweat glands. Papillary poroid hidradenoma is a very rare entity which belongs to poroid neoplasms, which represents 10% of sudoriferous tumours. Histologically, clear cell hidradenoma contains small ductular lumens, focal apocrine and squamoid change, and a less prominent vascular pattern than renal cell carcinoma. Nodular hidradenomas nhs are rare benign cutaneous adnexal neoplasms first described in 1949 as clear cell papillary carcinomas. Differential diagnosis these can be confused with many skin lesions.
Cytodiagonosis of cystic nodular hidradenoma presenting as thigh. Nodular hidradenoma is an unusual benign adnexal tumor arising from the excretory duct of sweat glands. A histogenetical origin in the skin adnexal glands was suspected due to its superficial location and immuno. The cells were lying in a mucoid background along with good number of cyst macrophages figure 2. Common sites are the face, axilla, trunk, thigh, scalp, upper extremity and pubic region. Nodular hidradenoma, also known as eccrine acrospiroma, is a benign adnexal skin tumour. It is also known as clear cell hidradenoma, acrospiroma, or solid cystic hidradenoma.
A single hidradenoma nodule may develop anywhere on the body, but is most likely to appear on the face, head, neck, legs, and arms. A study of histopathologic spectrum of nodular hidradenoma. Mar 16, 2020 a total of 15 cases with features of nodular hidradenoma with their age ranging from 18 years to 73 years were studied. Currently, there are no known methods to prevent hidradenoma of skin occurrence. Histopathology of the wide local excision of the tumour revealed benign nodular hidradenoma. Nodular hidradenoma is a rare tumor of skin which arises from distal excretory ducts of eccrine glands and it is also known as eccrine acrospiroma, clear cell hidradenoma and solidcystic hidradenoma. Fna from multiple sites yielded highly cellular smears with a dual cell population consisting of cells with small round nucleus scanty cytoplasm and polygonal cells with moderate to abundant cytoplasm. A diagnosis of benign adnexal neoplasm, suggestive of nodular hidradenoma was made. The pathology was controversial, originally identified as digital papillary adenocarcinoma, but ultimately identified as a benign poroidclear cell. Abstract nodular hidradenoma is a benign adnexal tumor with eccrine differentiation, occurring mainly in adults average age of 37. It occurs as a slow growing, nodular, solid or cystic, protruding cutaneous mass. Nodular hidradenoma definition of nodular hidradenoma by. Clear cell nodular hidradenoma involving the lymphatic. The only known risk factor is the prior presence of a benign hidradenoma molecular genetic changes in the cells of the hidradenocarcinoma have been found in some cases, but more studies must be performed before medical researchers can determine if a pattern exists.
Nests lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia may have marked vascularity small and large lumina are lined by cuboidal ductal cells or columnar secretory cells. A total of 15 cases with features of nodular hidradenoma with their age ranging from 18 years to 73 years were studied. Case of chondroid syringoma mimicking a nodular hidradenoma. Pigmented nodular hidradenoma masquerading as nodular malignant melanoma.
A nodular hidradenoma is a benign adnexal tumor of eccrine sweat gland origin. If the growth becomes unsightly, it may be surgically. We experienced the case of a large malignant nodular hidradenoma of the left upper arm in a 71yearold woman. Although it is diagnosed on histopathology, knowledge of. If an internal link led you here, you may wish to change the link to point directly to the intended article.
Nodular cystic hidradenoma over the gluteal region. Pdf nodular hidradenoma is a benign cutaneous neoplasm originated from ducts of eccrine. A rare case with cyto histopathological correlation. This disambiguation page lists articles associated with the same title. It can be easily misdiagnosed as a malignant neoplasm. Hidradenomas are commonly encountered on face, upper extremity, axilla, trunk, thigh, scalp and pubis. Nodular hidradenoma are difficult to be diagnosed on fnac. Hidradenocarcinoma is a very rare sweat gland tumour with an incidence as low as 0.
Webpathology is a free educational resource with 10231 high quality pathology images of benign and malignant neoplasms and related entities. Cytodiagonosis of cystic nodular hidradenoma presenting as. Hidradenoma refers to a benign adnexal tumor of the apical sweat gland. Mri revealed a large, lobular, poorly circumscribed, soft tissue mass at the left upper arm. Aug 24, 2016 the cause of hidradenocarcinoma is unknown. These tumours may behave in an aggressive fashion and wide surgical excision is the treatment of choice.
Nodular hidradenoma is an unusual benign adnexal tumor arising from. Poroid hidradenoma is a recently recognized variant of poroid neoplasm that should be differentiated from apocrine hidradenoma 1. Currently, there are no known methods to prevent the development of nodular hidradenoma of vulva. Eccrine hidradenoma, also known as clear cell hidradenoma, nodular hidradenoma, or solidcystic hidradenoma, generally presents as a solitary dermal nodule without any particular age or site distribution. Mar 16, 2020 webpathology is a free educational resource with 10231 high quality pathology images of benign and malignant neoplasms and related entities. Since then, less than 20 cases of poroid hidradenoma have been reported in the literature. The tumour range from locally recurring, low grade well differentiated tumour to highly aggressive high grade tumour with potential for local and distant metastasis to lymphnodes, bones and lungs.
Hidradenomas are rare benign adnexal neoplasms that encompass a morphological gamut with a range of differentiation. Nodular hidradenomas may be a sign of an underlying condition. Clear cell hidradenoma is a benign skin appendage tumor that may mimic conventionaltype renal cell carcinoma. Outcomesresolutions the prognosis for hidradenoma of skin is excellent with appropriate treatment, since it is a benign tumor. The present case report highlights the cytomorphological features of the nodular cystic hidradenoma. Variant of nodular hidradenoma with prevalence of cysts solid structures are present as well, as opposed to apocrine hidrocystoma. Request pdf a study of histopathologic spectrum of nodular hidradenoma hidradenomas are rare benign adnexal neoplasms that encompass a.
It is a benign neoplasm with eccrine differentiation, originally described by abenoza and ackerman in 1990. The proportion of the two cell types varies considerably between tumors, and there may be cells that have features between the two extremes. Malignant nodular hidradenoma mnh is a rare tumor of sweat gland known by many names in the literature. Thus the cytologic diagnosis was given as cystic hidradenoma. A cytohistological correlation on fineneedle aspiration cytology arnav roychoudhury1, shaffy thukral2 1senior resident, adesh institute of medical science and research, bathinda, punjab, india, 2assistant professor, adesh institute of medical science and research, bathinda, punjab, india. It usually occurs in elderly females and commonly involves the scalp, neck, trunk and extremities. Nodular hidradenoma is a rare benign adnexal neoplasm classified into eccrine and apocrine types that are more often observed in adults. Dec 03, 2019 pigmented nodular hidradenoma masquerading as nodular malignant melanoma. Hidradenoma papilliferum, also called papillary hidradenoma, is benign tumour arising from apocrine glands see sweat gland lesions. The lesion is a small solitary dermal or subcutaneous nodule, most commonly on the vulva histology of hidradenoma papilliferum. In 5 cases the cutaneous tumor showed small foci of intravascular deposits of neoplastic cells. A cytomorphological evaluation on fine needle aspiration cytology jitendra g nasit 1, gauravi dhruva 2 1 department of pathology, government medical college and sir sayajirao general hospital, baroda, gujarat, india 2 department of pathology, pandit deendayal upadhyay government medical college and hospital, rajkot, gujarat, india. Failure to identify its morphologic features may lead to a mistaken diagnosis and over treatment.
What is the prognosis of nodular hidradenoma of vulva. Outcomesresolutions nodular hidradenoma of vulva is a benign tumor. Nodular hidradenoma is an uncommon benign adnexal tumor arising from the eccrine sweat glands. Malignant nodular hidradenoma mnh or nodular hidradenocarcinoma is a rare malignant adnexal tumor that represented nodular hidradenoma, eccrine acrospiroma gross description. The tumor is characterized histologically by wellcircumscribed lobules located in the dermis that may be connected to the epidermis and. Histopathology established the diagnosis of nodular hidradenoma in all the cases. We describe five cases of nodular hidradenoma presenting as an expanding nodule on the zygoma case 1, left nostril case 2, right groin case 3, scalp case 4 and cystic lesion on back case 5. This is an openaccess article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited visit for more related articles at journal of patient care view pdf download pdf.
Hidradenocarcinoma may arise within a preexisting hidradenoma. Malignant nodular hidradenoma mnh or nodular hidradenocarcinoma is a rare malignant adnexal tumor that represented pdf full text. It usually occurs in elderly females and commonly involves the scalp, neck, trunk, and extremities. Dec 11, 2018 how can nodular hidradenoma of vulva be prevented. The lesion is a small solitary dermal or subcutaneous nodule, most commonly on the vulva. Malignant nodular hidradenoma of scalp researchgate. Nodular hidradenoma is a distinctive sweat gland neoplasm. Given the relative paucity of published data with only just over 50 case reports and small case series, there is little information available on the natural history and appropriate management for this disease. Hidradenoma presenting in a breast is exceedingly rare and this can potentially lead to misdiagnosis. Hidradenoma papilliferum is a wellcircumscribed dermal nodule, usually without connection to the overlying epidermis figure 1. The formation of these benign sweat gland tumors is one of the symptoms of eccrine acrospiroma. Nodular hidradenoma or clear cell hidradenoma is a rare skin adenexal tumor which arises from eccrine sweat glands. Malignant nodular hidradenoma is a rare skin appendageal tumor, and its imaging findings have not been previously described.
Hidradenocarcinoma is a rare sweat gland carcinoma, which has been described in a wide age range and at a wide range of anatomic sites. Nests lobules of cells resembling eccrine poroma with either clear cytoplasm or prominent squamous metaplasia may have marked vascularity. Although it is diagnosed on histopathology, knowledge of cytological features can help in their early detection. Nodular hidradenoma, also known as eccrine acrospiroma or clear cell hidradenoma, is a dermal adnexal tumor that most commonly appears in the head and neck area or the extremities. Skin adenexal tumors situated in the breast parenchyma are still very rare and is one of the differential diagnoses of breast tumors. Extracellular basement membrane like material was also noted. A cytohistological correlation on fineneedle aspiration cytology arnav roychoudhury1, shaffy thukral2 1senior resident, adesh institute of medical science and research, bathinda, punjab, india, 2assistant professor, adesh institute of. It usually presents as a single, small skincolored lesion, and is considered distinct from the closely related poroma. Nodular hidradenoma nh is a benign adnexal tumor that arises from either. Two cases of nodular hidradenoma of the breast with possibly different origins are reported.